Mosaic

Pre-clinical drug discovery intelligence as an MCP server. Query 800+ drug targets, 12K+ compounds, 46K+ papers, 18K+ clinical trials, and 16K+ patents through 44 specialized tools — 16 free for discovery, 28 Pro for competitive landscapes, whitespace, and thesis-grade analysis.

Quick Start

pip install mosaic-mcp

With Claude Desktop

Add to your claude_desktop_config.json:

{
  "mcpServers": {
    "mosaic": {
      "command": "mosaic-mcp",
      "env": {
        "DATABASE_URL": "postgresql://reader:[email protected]/mosaic_db?sslmode=require"
      }
    }
  }
}

With Claude Code

claude mcp add mosaic -- mosaic-mcp

Standalone

export DATABASE_URL="postgresql://..."
export MOSAIC_API_KEY="msk_..."       # Optional — for Pro tools
mosaic-mcp                             # stdio transport (default)
mosaic-mcp --transport sse --port 3001 # SSE for remote clients

Tools

Free Tier (16 tools) — discovery + workspace

Tool	Description
mosaic_search_targets	Search drug targets by name, gene symbol, or keyword
mosaic_get_target_profile	Comprehensive target dossier (biology, compounds, scores)
mosaic_get_target_compounds	Compounds tested against a target with SAR data
mosaic_get_target_patents	Patent landscape for a target
mosaic_get_target_papers	Literature for a target
mosaic_get_target_structure	3D structure and ligandability summary for a target
mosaic_kg_stats	Knowledge graph overview statistics
mosaic_list_indications	Available disease indications
mosaic_list_subindications	Sub-indications within an indication area
mosaic_subindication_breakdown	Per-target activity across sub-indications
mosaic_target_scores	Target attractiveness scoring
mosaic_target_wishlist_add	Add a target to your personal wishlist
mosaic_watchlist_create	Create a watchlist
mosaic_watchlist_add_item	Add an item to a watchlist
mosaic_watchlist_get	Retrieve a watchlist
mosaic_watchlist_list	List your watchlists

Pro Tier (28 additional tools) — analysis + whitespace

The committed-verdict layer. Includes the whitespace and differentiation tools: mosaic_synthetic_lethal_whitespace, mosaic_modality_gaps, mosaic_resistance_bypass_map, mosaic_find_undruggable_targets, mosaic_talent_migration, mosaic_emerging_signals, and mosaic_assess_druggability.

Plus the full analysis set: competitive landscape, pathway context, compound selectivity, indication landscape, target validation, clinical pipeline, compound analogs, target comparison, similar-target search, opportunity finding, organization portfolio, target network, mechanism of action, evidence maps, relation search, polypharmacology, clinical trial results, FDA regulatory status, drug comparison, drug repurposing candidates, and KOL discovery.

Data Coverage

Entity	Count
Drug Targets	801 (oncology + neuroscience + cardiovascular)
Compounds	12,756
Clinical Trials	18,324
Papers	46,354
Patents	16,168
Semantic Relations	13,704
Indications	15,013
Organizations	45,496

Configuration

Variable	Required	Description
DATABASE_URL	Yes	PostgreSQL connection string (Neon hosted or self-hosted)
MOSAIC_API_KEY	No	API key for Pro tool access
MOSAIC_TIER	No	Override tier (free, pro, enterprise)

License

Apache 2.0 for the MCP server tools. The hosted knowledge graph data requires a subscription for Pro-tier access.