Clinical Evidence

An MCP server aggregating clinical evidence from PubMed, ClinicalTrials.gov, and OpenFDA for medical necessity arguments in insurance litigation.

Features

• PubMed — 37M+ biomedical citations with full abstracts via NCBI E-utilities
• ClinicalTrials.gov — 500K+ clinical trials via API v2
• OpenFDA — Drug labels, adverse event reports (FAERS), approval history
• Comprehensive search — cross-source evidence aggregation in one tool call
• MCP protocol endpoint for Claude.ai and other MCP clients
• REST API with Swagger docs

MCP Tools

Tool	Description
pubmed_search	Search biomedical literature with abstracts
clinical_trial_search	Search trials by condition and intervention
clinical_trial_detail	Full trial details by NCT ID
drug_label	FDA indications, warnings, contraindications, adverse reactions
drug_adverse_events	FAERS adverse event reports — top reactions for a drug
drug_approvals	FDA drug approval history and submissions
medical_evidence_search	Comprehensive cross-source search for medical necessity

Quick Start

Connect via MCP (Claude.ai)

Add as a connector:

• URL: https://evidence.wyldfyre.ai/mcp
• Authentication: None required

REST API

# PubMed search
curl "https://evidence.wyldfyre.ai/pubmed/search?q=ketamine+treatment+resistant+depression&limit=5"

# Clinical trials
curl "https://evidence.wyldfyre.ai/trials/search?condition=major+depressive+disorder&intervention=ketamine"

# FDA drug label
curl "https://evidence.wyldfyre.ai/fda/labels?drug=ozempic"

# Adverse events
curl "https://evidence.wyldfyre.ai/fda/adverse-events?drug=ozempic"

# Drug approvals
curl "https://evidence.wyldfyre.ai/fda/approvals?drug=metformin"

Full Swagger docs: https://evidence.wyldfyre.ai/docs

Self-Hosting

pip install -r requirements.txt

# Optional: set API keys for higher rate limits
export NCBI_API_KEY="your-key"      # 10 req/s (vs 3 without)
export OPENFDA_API_KEY="your-key"   # 120K/day (vs 1K without)

# Start REST API
uvicorn app.main:app --host 0.0.0.0 --port 8110

# Start MCP server (separate process)
python run_mcp.py

API keys are free:

• NCBI: https://www.ncbi.nlm.nih.gov/account/ → Settings → API Key
• OpenFDA: https://open.fda.gov/apis/authentication/

Data Sources

Source	Coverage	Auth	Rate Limits
PubMed	37M+ citations	Optional key	3/s free, 10/s with key
ClinicalTrials.gov	500K+ trials	None	Not published
OpenFDA	Drug labels, FAERS, approvals	Optional key	1K/day free, 120K/day with key

Architecture

Claude.ai / MCP Client
        │
        ▼ MCP Protocol
evidence.wyldfyre.ai/mcp (:8111)
        │
        ├── PubMed (NCBI E-utilities)
        ├── ClinicalTrials.gov (API v2)
        └── OpenFDA (labels, events, approvals)

License

MIT