Guide to Pharmacology

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Peer-reviewed pharmacological targets and ligands from the IUPHAR/BPS Guide to PHARMACOLOGY.

by pipeworx-io

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About

Peer-reviewed pharmacological targets and ligands from the IUPHAR/BPS Guide to PHARMACOLOGY.

README

IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) MCP — keyless.

Part of Pipeworx — an MCP gateway connecting AI agents to 1394+ live data sources.

Tools

Tool	Description
`search_ligands`	Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for drug ligands by name. Returns matching ligands with their GtoPdb ligand id, type (e.g. Synthetic organic, Peptide, Antibody, Metabolite), and approval status. Use the returned ligand id with ligand_interactions to find which protein targets it acts on. Keyless. Complements ChEMBL/DrugBank.
`search_targets`	Search the Guide to PHARMACOLOGY (IUPHAR/BPS) — an expert-curated pharmacology database — for protein targets by name. Returns matching targets with their GtoPdb target id, abbreviation, and type (e.g. GPCR, CatalyticReceptor, Enzyme, Transporter). Use the returned target id with target_interactions to find ligands that bind it. Keyless. Complements ChEMBL/DrugBank.
`target_interactions`	List the quantitative ligand interactions for a protein target in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb target id (from search_targets), returns the ligands acting on it with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.
`ligand_interactions`	List the quantitative target interactions for a drug ligand in the Guide to PHARMACOLOGY (IUPHAR/BPS). Given a GtoPdb ligand id (from search_ligands), returns the protein targets it acts on with interaction type (Agonist/Antagonist/Inhibitor/etc.), action, and binding affinity (e.g. pKi/pIC50). Keyless.

Quick Start

Add to your MCP client (Claude Desktop, Cursor, Windsurf, etc.):

{
  "mcpServers": {
    "guidetopharmacology": {
      "url": "https://gateway.pipeworx.io/guidetopharmacology/mcp"
    }
  }
}

Or connect to the full Pipeworx gateway for access to all 1394+ data sources:

{
  "mcpServers": {
    "pipeworx": {
      "url": "https://gateway.pipeworx.io/mcp"
    }
  }
}

Using with ask_pipeworx

Instead of calling tools directly, you can ask questions in plain English:

ask_pipeworx({ question: "your question about Guidetopharmacology data" })

The gateway picks the right tool and fills the arguments automatically.

License

MIT

from github.com/pipeworx-io/mcp-guidetopharmacology

Install Guide to Pharmacology in Claude Desktop, Claude Code & Cursor

Recommended · one command, every IDE

unyly install guide-to-pharmacology

Installs into Claude Desktop, Claude Code, Cursor & VS Code — handles npx, uvx and build-from-source repos for you.

First time? Get the CLI: curl -fsSL https://unyly.org/install | sh

Or configure manually

Run in your terminal:

claude mcp add guide-to-pharmacology -- npx -y @pipeworx/mcp-guidetopharmacology

Step-by-step: how to install Guide to Pharmacology

Install Guide to Pharmacology in Claude Desktop Install Guide to Pharmacology in Claude Code Install Guide to Pharmacology in Cursor Install Guide to Pharmacology in VS Code

FAQ

Is Guide to Pharmacology MCP free?

Yes, Guide to Pharmacology MCP is free — one-click install via Unyly at no cost.

Does Guide to Pharmacology need an API key?

No, Guide to Pharmacology runs without API keys or environment variables.

Is Guide to Pharmacology hosted or self-hosted?

Self-hosted: the server runs locally on your machine via the install command above.

How do I install Guide to Pharmacology in Claude Desktop, Claude Code or Cursor?

Open Guide to Pharmacology on unyly.org, pick your client tab (Claude Desktop, Claude Code, Cursor) and press Install — the config is generated automatically, no JSON editing.

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